Nanosafety and Nanotoxicology: Current Opportunities and Challenges
A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Environmental Nanoscience and Nanotechnology".
Deadline for manuscript submissions: 28 June 2024 | Viewed by 555
Special Issue Editors
Interests: genotoxicity assays; cytotoxicity tests; DNA and chromosomal damage evaluation; comet assay; nanomaterial safety testing
Special Issues, Collections and Topics in MDPI journals
Interests: genotoxicity assays; cytotoxicity tests; DNA and chromosomal damage evaluation; comet assay; nanomaterial safety testing
Special Issue Information
Dear Colleagues,
The increasing use of nanomaterials in a wide range of consumer products arises from the need to define a correct strategy for hazard identification and risk assessment. In the last few years, a large amount of data on cytotoxicity and genotoxicity have been published and produced in a wide range of collaborative European-funded projects, but the key mechanisms involved in the cytotoxic and genotoxic responses of nanomaterials are still controversial. In addition, the assay conditions for cytotoxicity and genotoxicity testing are currently being questioned, especially in a regulatory context. In this framework, to facilitate the safe development and use of nanomaterials, the European Commission is supporting the revision/adaptation of the existing safety assessment methods as well as the validation of new approach methodologies and their integration into the risk assessment process (OECD Testing Guidelines and/or Guidance Documents).
This Special Issue is open to contributions on studies on the cytotoxicity and genotoxicity of nanomaterials regarding a) the conditions for cytotoxicity and genotoxicity testing, such as the cell line(s) to be used, the maximum dose/concentration, and the rationale for nanomaterial-positive controls; b) advanced biological models for in vitro cytotoxicity and genotoxicity testing; c) Safe-and Sustainable by-Design (SSbD) approaches; d) in silico methodologies, like QSAR, grouping, and read-across; and e) criteria for the efficient reuse of existing nanosafety data, as recently established through the FAIR (Findable, Accessible, Interoperable, and Reusable) guiding principle.
Dr. Cristina Andreoli
Dr. Andrea Zijno
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- nanomaterial cytotoxicity testing
- nanomaterial genotoxicity testing
- nanosafety
- new approach methodologies (NAMs)
- safe and sustainable-by-design (SSbD) approaches
- in silico methodologies
- FAIR approach
