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Journals
Microorganisms
Special Issues
Parasitic Diseases in Humans and Animals
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Parasitic Diseases in Humans and Animals

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Parasitology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1520

Special Issue Editor

Dr. Loka Raghu Kumar Penke

E-Mail Website
Guest Editor
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
Interests: asthma; cellular and molecular biology; gene expression; gene regulation

Special Issue Information

Dear Colleagues,

In a changing world, humans and animals are under continuous threat, and this promotes the spread of disease. Among these diseases, parasitic infections are common, with parasites frequently blamed for being reservoirs for diseases affecting domestic animals and humans. The transmission can be vector-borne (Leishmania, Trypanosoma, Dirofilaria, Thelazia) or by contact or fomites (ectoparasites, hookworms), but it can also be through drinking contaminated water (Giardia, Cryptosporidium) or eating contaminated meat (Toxoplasma, Trichinella), vegetables, and fruits (Echinococcus, Baylisascaris).

The aim of this Special Issue is to give an overall picture of parasitic diseases, including the pathology, treatment, diagnosis, epidemiology, and transmission in the context of a “one health” approach. With this purpose, we welcome research articles, reviews, and short communications related to the subject. We hope to gather cutting-edge information on this topic and hope that it will improve on the current body of research related to humans and animals.

Dr. Loka Raghu Kumar Penke
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • parasitic diseases
  • Leishmania
  • Trypanosoma
  • Dirofilaria
  • Thelazia
  • animals and humans

Published Papers (1 paper)

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Review

22 pages, 4182 KiB  
Review
Fused Enzyme Glucose-6-Phosphate Dehydrogenase::6-Phosphogluconolactonase (G6PD::6PGL) as a Potential Drug Target in Giardia lamblia, Trichomonas vaginalis, and Plasmodium falciparum
by Laura Morales-Luna, Montserrat Vázquez-Bautista, Víctor Martínez-Rosas, Miriam Abigail Rojas-Alarcón, Daniel Ortega-Cuellar, Abigail González-Valdez, Verónica Pérez de la Cruz, Roberto Arreguin-Espinosa, Eduardo Rodríguez-Bustamante, Eden Rodríguez-Flores, Beatriz Hernández-Ochoa and Saúl Gómez-Manzo
Microorganisms 2024, 12(1), 112; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms12010112 - 5 Jan 2024
Viewed by 1313
Abstract
Several microaerophilic parasites such as Giardia lamblia, Trichomonas vaginalis, and Plasmodium falciparum are major disease-causing organisms and are responsible for spreading infections worldwide. Despite significant progress made in understanding the metabolism and molecular biology of microaerophilic parasites, chemotherapeutic treatment to control [...] Read more.
Several microaerophilic parasites such as Giardia lamblia, Trichomonas vaginalis, and Plasmodium falciparum are major disease-causing organisms and are responsible for spreading infections worldwide. Despite significant progress made in understanding the metabolism and molecular biology of microaerophilic parasites, chemotherapeutic treatment to control it has seen limited progress. A current proposed strategy for drug discovery against parasitic diseases is the identification of essential key enzymes of metabolic pathways associated with the parasite’s survival. In these organisms, glucose-6-phosphate dehydrogenase::6-phosphogluconolactonase (G6PD:: 6PGL), the first enzyme of the pentose phosphate pathway (PPP), is essential for its metabolism. Since G6PD:: 6PGL provides substrates for nucleotides synthesis and NADPH as a source of reducing equivalents, it could be considered an anti-parasite drug target. This review analyzes the anaerobic energy metabolism of G. lamblia, T. vaginalis, and P. falciparum, with a focus on glucose metabolism through the pentose phosphate pathway and the significance of the fused G6PD:: 6PGL enzyme as a therapeutic target in the search for new drugs. Full article
(This article belongs to the Special Issue Parasitic Diseases in Humans and Animals)
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