Using In Vitro and Ex Vivo Models to Evaluate Strategies for Drug Delivery Improvement

Dear Colleagues,

This special issue covers topics related to drug delivery improvement that have been evaluated using applicable in vitro and/or ex vivo models.  These models may include epithelial cell lines grown as monolayers on insert membranes and/or excised epithelial tissues mounted in Ussing type diffusion chambers for measurement of drug permeation.  Contributions on models representing any route of drug administration will be accepted including gastrointestinal tract epithelium (oral administration), nasal respiratory and olfactory epithelium (intranasal and intra-respiratory administration), mouth, cheek, and tongue epithelium (buccal and/or sublingual administration) and the skin (transdermal administration) amongst others.  Drug delivery improvements achieved by means of formulation approaches such as carrier systems (e.g., nanoparticulate systems and cyclodextrin inclusion complexes), smart delivery systems (thermosensitive gel systems), drug absorption enhancers (e.g., chitosan, surfactants etc.) or by enhancement of solubility (e.g., amorphous solid dispersions) will be considered for inclusion in the special issue.

Dr. Dewald Steyn
Prof. Dr. Sias Hamman
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• bioenhancers
• epithelial tissue
• formulation approaches
• in vitro models
• ex vivo models
• nanoparticulate systems
• permeation enhancement
• smart delivery systems
• solubility enhancement