Inflammaging, a coexistence of inflammation and aging, is a persistent, systemic, low-grade inflammation seen in the geriatric population. Various natural compounds have been greatly explored for their potential role in preventing and treating inflammaging.
Withania somnifera has been used for thousands of years
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Inflammaging, a coexistence of inflammation and aging, is a persistent, systemic, low-grade inflammation seen in the geriatric population. Various natural compounds have been greatly explored for their potential role in preventing and treating inflammaging.
Withania somnifera has been used for thousands of years in traditional medicine as a nutraceutical for its numerous health benefits including regenerative and adaptogenic effects. Recent preclinical and clinical studies on the role of
Withania somnifera and its active compounds in treating aging, inflammation, and oxidative stress have shown promise for its use in healthy aging. We discuss the chemistry of
Withania somnifera, the etiology of inflammaging and the protective role(s) of
Withania somnifera in inflammaging in key organ systems including brain, lung, kidney, and liver as well as the mechanistic underpinning of these effects. Furthermore, we elucidate the beneficial effects of
Withania somnifera in oxidative stress/DNA damage, immunomodulation, COVID-19, and the microbiome. We also delineate a putative protein–protein interaction network of key biomarkers modulated by
Withania somnifera in inflammaging. In addition, we review the safety/potential toxicity of
Withania somnifera as well as global clinical trials on
Withania somnifera. Taken together, this is a synthetic review on the beneficial effects of
Withania somnifera in inflammaging and highlights the potential of
Withania somnifera in improving the health-related quality of life (HRQoL) in the aging population worldwide.
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