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Special Issue Editor

Dr. João Marcus Oliveira Andrade

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Guest Editor

Department of Pathophysiology, State University of Montes Claros (Universidade Estadual de Montes Claros - Unimontes), Montes Claros, MG, Brazil
Interests: obesity; obesity-related diseases; nutrition; metabolism; adipose tissue; skeletal muscle; liver; placenta; thermogenesis; functional food; metabolic syndrome

Special Issue Information

Dear Colleagues,

Obesity is a chronic disease characterized by excessive adipose tissue accumulation in the body. Its prevalence has significantly increased in recent decades. The causes of obesity are multifactorial and involve the interaction of genetic, metabolic, social, behavioral, and cultural factors.

Obesity has emerged as a significant public health issue due to its numerous health consequences, which range from an elevated risk of premature death to the development of serious conditions such as type 2 diabetes mellitus, cancer, nonalcoholic fatty liver disease, and cardiovascular diseases. These conditions directly impact the quality of life of affected individuals.

Therefore, this Special Issue aims to address the need for a better understanding of the pathophysiological mechanisms underlying obesity and its related diseases. Additionally, it aims to explore therapeutic and preventive strategies for these conditions.

Dr. João Marcus Oliveira Andrade
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

obesity
metabolic diseases
metabolic syndrome
diabetes/insulin resistance
nonalcoholic fatty liver disease
adipose tissue
liver
skeletal muscle
non-pharmacological treatment
drugs for obesity and related diseases

Published Papers (1 paper)

Research

12 pages, 2081 KiB

Open AccessArticle

Dynamics of Serum Inflammatory Markers and Adipokines in Patients: Implications for Monitoring Abnormal Body Weight: Preliminary Research

by Malwina Zimowska, Marta Rolbiecka, Klaudia Antoniak-Pietrynczak, Marta Jaskulak and Katarzyna Zorena

Metabolites 2024, 14(5), 260; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo14050260 - 1 May 2024

Viewed by 513

Abstract

This study aimed to investigate the influence of abnormal body weight on inflammatory markers and adipokine levels across varied body mass index (BMI) categories. The cohort included 46 participants categorized into normal BMI (group I; n = 19), overweight (group II; n = 14), and obesity (group III; n = 13). Inflammatory markers (hsCRP and IL-6) and adipokines (Adiponectin, Leptin, Nesfatin-1, and Zinc-α2-glycoprotein) were assessed to discern effective indicators of inflammation in individuals with abnormal body weight. Additionally, the full lipid profile was also assessed (total cholesterol, triglycerides, LDL-C, HDL-C). The results indicated significant biochemical changes, particularly in IL-6 and Leptin levels, in participants with a BMI over 25. The levels of ZAG protein were negatively correlated with the HDL-C and LDC-L levels with statistical significance (Pearson: −0.57, p = 0.001, and Pearson: −0.41, p = 0.029, for HDL-C and LDL-C, respectively), suggesting that the level of ZAG is also inversely proportional to the amount of cholesterol. Statistical analyses revealed decreased Zinc-α2-glycoprotein (ZAG) levels and increased Adiponectin, Leptin, and IL-6 levels in individuals with abnormal body weight. Correlation analyses demonstrated a statistically significant upward trend for IL-6 (p = 0.0008) and Leptin (p = 0.00001), with a similar trend observed for hsCRP without statistical significance (p = 0.113). IL-6 levels in the overweight group were 158.71% higher than in the normal-weight group, while the obese group exhibited a 229.55% increase compared to the normal-weight group. No notable changes have been recorded for the levels of Nesfatin-1. Based on our results, we propose IL-6, Leptin, and ZAG as potential biomarkers for monitoring interventions and assessing patient conditions in those with abnormal BMIs. Further research with a larger patient cohort is warranted to validate these correlations in overweight and obese individuals. Full article

(This article belongs to the Special Issue Improvement of Metabolic Profile of Obesity and Obesity-Related Injury)

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