Molecular Pathology Research on Pregnant Uterus, Uterine Infections and Diseases

Dear Colleagues,

Understanding the physiological–pathological mechanisms of pregnancy through molecular research in uterine biology can have an impact on the labor and the manner of birth, particularly during cesarean sections, and its long-term effects. Understanding the biological processes at play during pregnancy and childbirth may help develop fresh approaches to management of labor and delivery-related issues, enhancing both the mother's and the baby's health. To better understand the molecular mechanisms underlying uterine biology and pregnancy, and to apply these discoveries to everyday clinical practice, further study is required. It is necessary to examine the molecular mechanisms that underlie the uterine response to pregnancy and delivery, as well as that of other organs, and their long-term effects. Several chemical mechanisms, including hormones, cytokines, and growth factors, control the biological changes that occur in the uterus and the body during pregnancy. It is crucial to comprehend these procedures if we are to handle pregnancy, labor, and birthing difficulties more effectively. The molecular mechanisms of uterine contractions, including the function of oxytocin, calcium signaling, and ion channels, have been the subject of recent research. These could be crucial in the creation of novel induction drugs and, ideally, in a decline in the rate of cesarean sections. Studies that pinpoint the growth factors, cytokines, interleukins, TNF, and other molecular pathways implicated in uterine repair may help advance our understanding of these pathways, accelerate healing, and reduce problems. To this, we must add other problems that intersect with the pregnant uterus, including uterine infections and related pathologies. The term uterine infection indicates that the uterus is contaminated with pathogenic organisms. In addition to reducing reproductive efficiency, uterine infections usually increase herd health costs, often reduce feed consumption, and cause an appreciable reduction in milk production. Furthermore, intrauterine bacterial infections are connected to other pathological processes, including endometriosis. This Special Issue focuses on molecular research into these intersecting pathological issues.

Prof. Dr. Andrea Tinelli
Guest Editor

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• pregnancy
• labor
• delivery
• uterine infection
• endometritis
• endometriosis