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Molecular Research in Pregnancy, Childbirth, and Related Complications
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Molecular Research in Pregnancy, Childbirth, and Related Complications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 26 July 2024 | Viewed by 141

Special Issue Editor

Prof. Dr. Nicoletta Di Simone

E-Mail Website
Guest Editor
1. Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072 Milano, Italy
2. IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Italy
Interests: high risk pregnancy; recurrent miscarriage; preterm birth; preeclampsia; autoimmune diseases in pregnancy; diabetes in pregnancy; infertility; menopause
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue, titled “Molecular Research in Pregnancy, Childbirth, and Related Complications”, aims to explore the underlying molecular mechanisms of pregnancy complications. Our objective is to clarify the emerging role of different molecular pathways in the principal diseases associated with pregnancy, including preeclampsia, HELLP syndrome, gestational diabetes, preterm labor, fetal growth restriction, placenta previa, recurrent pregnancy loss, stillbirth. We believe that only understanding the biological process it is possible to identify new biomarkers that can be used in clinical practice in order to recognize at-risk patients. Moreover, focusing the attention on the principal pathways involved in the different disease it is achievable the hypothesis of new treatment strategies. This Special Issue aims to collect original articles, reviews and other contributions on the latest studies on the cellular and molecular mechanisms of the pregnancy-related diseases, including their application in diagnostic, terapeutic and prognostic fields.

Prof. Dr. Nicoletta Di Simone
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pregnancy complications 
  • preeclampsia 
  • gestational hypertension 
  • HELLP syndrome 
  • gestational diabetes 
  • preterm labor
  • fetal growth restriction 
  • placenta previa 
  • recurrent pregnancy loss 
  • stillbirth

Published Papers (1 paper)

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Review

17 pages, 368 KiB  
Review
First Trimester Placental Biomarkers for Pregnancy Outcomes
by Martina Cristodoro, Martina Messa, Giovanni Tossetta, Daniela Marzioni, Marinella Dell’Avanzo, Annalisa Inversetti and Nicoletta Di Simone
Int. J. Mol. Sci. 2024, 25(11), 6136; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms25116136 (registering DOI) - 2 Jun 2024
Abstract
The placenta plays a key role in several adverse obstetrical outcomes, such as preeclampsia, intrauterine growth restriction and gestational diabetes mellitus. The early identification of at-risk pregnancies could significantly improve the management, therapy and prognosis of these pregnancies, especially if these at-risk pregnancies [...] Read more.
The placenta plays a key role in several adverse obstetrical outcomes, such as preeclampsia, intrauterine growth restriction and gestational diabetes mellitus. The early identification of at-risk pregnancies could significantly improve the management, therapy and prognosis of these pregnancies, especially if these at-risk pregnancies are identified in the first trimester. The aim of this review was to summarize the possible biomarkers that can be used to diagnose early placental dysfunction and, consequently, at-risk pregnancies. We divided the biomarkers into proteins and non-proteins. Among the protein biomarkers, some are already used in clinical practice, such as the sFLT1/PLGF ratio or PAPP-A; others are not yet validated, such as HTRA1, Gal-3 and CD93. In the literature, many studies analyzed the role of several protein biomarkers, but their results are contrasting. On the other hand, some non-protein biomarkers, such as miR-125b, miR-518b and miR-628-3p, seem to be linked to an increased risk of complicated pregnancy. Thus, a first trimester heterogeneous biomarkers panel containing protein and non-protein biomarkers may be more appropriate to identify and discriminate several complications that can affect pregnancies. Full article
(This article belongs to the Special Issue Molecular Research in Pregnancy, Childbirth, and Related Complications)
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