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Research on Virus-Induced Cellular and Molecular Responses

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 631

Special Issue Editor


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Guest Editor
Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA
Interests: autophagic degradation of protein aggregation; meiotic translational control; virology and insect immunity; virus infectivity

Special Issue Information

Dear Colleagues,

A virus is an intracellular parasite. Therefore, the initial stage of virus invasion is a battle between the virus and the cell it parasitizes. For multicellular organisms, in addition to the host’s immune mechanisms, cells themselves have developed some defense mechanisms against viral invasions, such as autophagy.

On the other hand, once the virus has invaded the cell, it will alter the internal environment of the cell through a series of cellular molecular responses to adapt to its survival and replication. However, these processes can trigger inflammation and even lead to significant cellular stress, ultimately resulting in cancer.

Therefore, the theme of this Special Issue helps us understand the mechanisms of how cells resist virial invasion, as well as the principles behind some carcinoma viruses. By welcoming original research and review articles on this theme, we are trying to integrate the current knowledge and help virologists, immunologists, and cellular molecular biologists to work together closely to address the viral diseases issues that have affected human beings for centuries.

We look forward to receiving your contributions.

Dr. Rudian Zhang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • virus infectivity
  • infectious diseases
  • cellular stress
  • autophagy

Published Papers (1 paper)

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Review

23 pages, 7534 KiB  
Review
Insights into the Activation of Unfolded Protein Response Mechanism during Coronavirus Infection
by Panagiotis Keramidas, Maria Pitou, Eleni Papachristou and Theodora Choli-Papadopoulou
Curr. Issues Mol. Biol. 2024, 46(5), 4286-4308; https://0-doi-org.brum.beds.ac.uk/10.3390/cimb46050261 - 5 May 2024
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Abstract
Coronaviruses represent a significant class of viruses that affect both animals and humans. Their replication cycle is strongly associated with the endoplasmic reticulum (ER), which, upon virus invasion, triggers ER stress responses. The activation of the unfolded protein response (UPR) within infected cells [...] Read more.
Coronaviruses represent a significant class of viruses that affect both animals and humans. Their replication cycle is strongly associated with the endoplasmic reticulum (ER), which, upon virus invasion, triggers ER stress responses. The activation of the unfolded protein response (UPR) within infected cells is performed from three transmembrane receptors, IRE1, PERK, and ATF6, and results in a reduction in protein production, a boost in the ER’s ability to fold proteins properly, and the initiation of ER-associated degradation (ERAD) to remove misfolded or unfolded proteins. However, in cases of prolonged and severe ER stress, the UPR can also instigate apoptotic cell death and inflammation. Herein, we discuss the ER-triggered host responses after coronavirus infection, as well as the pharmaceutical targeting of the UPR as a potential antiviral strategy. Full article
(This article belongs to the Special Issue Research on Virus-Induced Cellular and Molecular Responses)
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