Oncogenic Signal Transduction Processes: Regulation, Biomarkers and Therapy Targets
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Microenvironment".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 305
Special Issue Editors
Interests: RAS oncogenes; RAS signaling pathways; RAS activation by guanine nucleotide exchange factors (GEFs); mammalian GEFs of the SOS and GRF families; inhibitors of RAS-driven tumors; cancer molecular biology; signal transduction
Special Issues, Collections and Topics in MDPI journals
Interests: cancer biology and immunotherapy research; RAS proteins and GEF activation mechanisms; inhibitors of RAS-driven tumors; signal transduction mechanisms in RAS-associated pathways; preclinical assays for evaluating RAS-related therapeutics; integration of immunology and RAS signaling in tumor microenvironment
Interests: RAS GTPases; signaling; guanine nucleotide exchange factors; RASopathies; lung development; inhibitor screening; interactome
Special Issue Information
Dear Colleagues,
An integrated, comprehensive view of the molecules, processes and signaling pathways that are relevant in tumorigenesis is of paramount importance in cellular and molecular biomedicine. Deregulated cell signaling drives cancer. A wide variety of genetic mutations and/or transcriptional or translational alterations impacting relevant signaling pathways and partners are known to underlie tumor initiation and development. Improving our knowledge regarding these alterations in oncogenic signal transduction is essential to achieve a complete understanding of the progressive pathophysiological changes leading to cancer. A deeper characterization of these altered signaling molecules and processes should also foster the identification of new biomarkers and therapeutic targets that are instrumental for future clinical interventions against tumoral diseases.
Publications on this subject are dispersed throughout the scientific literature. We believe that this Special Issue will provide a great opportunity to bring together, in a single place, a relevant set of papers dealing with recent data on altered signal transduction events, molecules or mechanisms that may account for the various phenotypic defects, at the genetic, metabolism or the tumor microenvironment levels, usually associated with cancer development.
This Special Issue should be useful for both researchers and students interested in cancer signaling. Aimed at providing an inclusive view of the cellular signaling alterations that occur in cancer, we invite both reviews and original articles focusing on the main cancer signaling pathways and the crosstalk among them.
Dr. Eugenio Santos
Dr. Rosula Garcia-Navas
Dr. Alberto Fernández-Medarde
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- oncogenic signal transduction, tumorigenesis and metastasis
- signaling pathways in cancer metabolism
- cell signaling in the tumor microenvironment
- oncogenic signaling, biomarkers and molecular diagnostics
- oncogenic signaling, therapeutic targets and treatment
- interplay among signaling pathways in cancer
- tumor cell pathophysiology and signaling
