Cellular and Molecular Mechanism in Periodontal Diseases II

Dear Colleagues,

You are cordially invited to contribute to this Special Issue entitled “Cellular and Molecular Mechanisms in Periodontal Disease”.

Periodontitis is an extremely complex and multifactorial disease, leading to the destruction of all the components of the periodontium, namely, gingiva, periodontal ligament, cementum, and the alveolar bone. It is the main cause of tooth loss and is also associated with several systemic disorders. Nowadays, periodontitis is considered a major public health problem worldwide.

The mechanisms underlying the initiation and progression of periodontal disease are very complex and not entirely understood. The maintaining of oral health depends mainly on the homeostasis between oral microbiome and host immune systems, and its disruption is a major event in the initiation of periodontal disease. Host microbial homeostasis in the oral cavity could be disrupted by ecological, genetic, and epigenetic factors, as well as by subverting the host immune system by some keystone pathogens. The progression of periodontal disease and tissue destruction is mainly forced by the immune response to overgrowing oral biofilms. The initial role of the immune response is the elimination of the invading pathogens, but its initiation, progression, and resolution need to be tightly controlled on the cellular level. A dysregulated immune response is considered to be the major cause of periodontal tissue damage. The immune response is driven by different immune cell types, tissue-resident cells, and numerous pro- and anti-inflammatory cytokines. Understanding the exact mechanisms involved in the progression and control of the immune response is crucially important for the development of new strategies for periodontitis treatment and prevention.

This Special Issue welcomes in vitro, animal, and clinical studies on the cellular and molecular mechanisms involved in the maintenance of oral host–microbe homeostasis and the regulation of the immune response in periodontitis.

Prof. Dr. Oleh Andrukhov
Guest Editor

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• periodontal disease
• host–microbial homeostasis
• periodontal tissue destruction
• immune response
• innate immunity
• polymorphonuclear leukocytes
• macrophages
• T cells
• B cells
• cytokines
• regulation of inflammation