Therapeutic Target in Cardiovascular Disease

Dear Colleagues,

Regulated calcium handling in each cardiac cell is essential for optimal electrical and mechanical function of the heart. Abnormalities in calcium handling in the heart are associated with cardiovascular diseases such as heart failure and atrial fibrillation, including arrhythmic cardiomyopathy. The exact role of calcium in the progression of these diseases is a result of complex interactions among many electrophysiological targets and signaling systems, and mechanisms of heart disease development, such as cardiac fibrosis, oxidative stress, and changes in ion channel function, are being widely studied to date. Despite more refined therapeutic targets proposed in recent years, most currently available pharmacological treatments are still limited by incomplete efficacy, side effects, and significant recurrence rates. On this basis, this special issue aims to provide diverse theoretical bases and creative potential therapeutic strategies for the prevention and treatment of cardiac diseases, and to present important therapeutic targets and clinically relevant mechanisms.

Dr. Hyelim Park
Guest Editor

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• cardiac disease
• arrhythmia
• cardiac remodeling
• therapeutic target