Regulation of Global and Specific mRNA Translation during Cellular Division
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Proliferation and Division".
Deadline for manuscript submissions: closed (28 February 2021)
Special Issue Editor
Special Issue Information
Dear Colleagues,
Protein synthesis is a multistep/multifactorial process of mRNA translation. The act of cellular division, a multistep/multifactorial process by itself, involves massive regulation at the levels of translation initiation and elongation. A combined global protein synthesis attenuation and temporal translation enhancement of specific mRNAs is essential for successful execution of mitosis and generation of immediate critical supply to the daughter cells. Microbes, early eukaryotes, animal cells and plant cells developed strategies to cope with various regulation challenges. Post-translation modification of kinases and translation factors largely govern their activity/availability. Temporal changes of RNA binding proteins; protein–protein and protein–RNA interactions regulate specific mRNA translation in a concerted manner to execute a fine-tuned program of protein synthesis to guarantee correct levels at the correct time. Despite accumulated knowledge about the role of trans-acting RNA elements and cis-acting factors, regulation of 5'cap-dependent and -independent translation during mitosis remains largely mysterious.
In this Special Issue of Cells, I invite you to contribute, in the form of either original research articles, reviews or shorter perspective articles on all aspects related to the theme of “Regulation of Global and Specific mRNA Translation During Cellular Division”. Expert articles describing mechanistic, functional, cellular, biochemical, or general aspects of translation regulation during the mitosis phase of the cell cycle are welcome. Relevant topics include, but are not limited to:
- Regulation at the initiation level
- Regulation at the elongation level
- Specialized ribosomes
- The role of CDK1
- Link to cancer
- Link to metabolism/energy
- Mitochondria involvement
- Meiosis
- Division towards differentiation
- IRES-dependent translation
- Stalled ribosomes
- Cell growth vs. cell division
- High resolution of translation timing
- Omics
- Localized translation
- Post-translation modification of translation factors
- tRNA biology
- Live bio-imaging
Dr. Orna Elroy-Stein
Guest Editor
Manuscript Submission Information
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