Fat Mass Index Associated with Blood Pressure Abnormalities in Children with Chronic Kidney Disease
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients and Study Design
2.2. Data and Specimens
2.3. Anthropometric Measurements
2.4. Office BP and ABPM Measurements
2.5. Cardiovascular Assessments
2.6. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristics | DXA Group | Total |
---|---|---|
n = 63 | n = 101 | |
Age, years | 13.4 (10.4–15.7) | 10 (5.9–14.9) * |
Male | 37 (58.7) | 60 (59.4%) |
CAKUT | 36 (57.1%) | 65 (64.4%) |
CKD stage | ||
G1 | 40 (63.5%) | 70 (69.3%) |
G2 | 16 (25.4%) | 19 (18.8%) |
G3 | 5 (7.9) | 10 (9.9%) |
G4 | 2 (3.2) | 2 (2%) |
Body height, percentile | 50 (15–75) | 25 (15–50) |
Body weight, percentile | 64 (35–60) | 50 (15–75) |
Body mass index, percentile | 64 (28–87) | 56 (30–80) |
Body mass index z-score | 0.37 (−0.57–1.11) | 0.15 (−0.54–0.84) |
Systolic blood pressure, percentile | 50 (50–95) | 50 (50–93) |
Diastolic blood pressure, percentile | 50 (50–90) | 50 (50–90) |
Creatinine, mg/dL | 0.6 (0.5–0.86) | 0.51 (0.42–0.76) * |
eGFR, mL/min/1.73 m2 | 101.4 (80.2–117.1) | 104 (83–124) |
Urine total protein-to-creatinine ratio, mg/g | 64.2 (37.3–410.3) | 63.2 (38.4–207.5) |
Hemoglobin, g/dL | 13.7 (13–14.9) | 13.4 (12.7–14.3) |
Uric acid, mg/dL | 5.7 (4.5–6.7) | 5.3 (4.2–6.4) |
Sodium, mEq/L | 141 (140–142) | 141 (140–142) |
Potassium, mEq/L | 4.3 (4.1–4.5) | 4.4 (4.2–4.5) |
Calcium, mg/dL | 9.5 (9.1–9.9) | 9.7 (9.3–9.9) |
Phosphate, mg/dL | 4.7 (4.3–5.1) | 4.9 (4.5–5.3) |
LDL-cholesterol, mg/dL | 83 (67–102) | 87 (70–105) |
Total cholesterol, mg/dL | 162 (141–185) | 163 (146–191) |
Triglyceride, mg/dL | 67 (53–102) | 67 (52–102) |
Characteristics | Abnormal ABPM | Normal ABPM | p Value |
---|---|---|---|
n = 40 | n = 23 | ||
Age, years | 14.4 (11.4–16.4) | 11.7 (9.6–14.5) | 0.006 |
Male | 27 (67.5%) | 10 (43.5%) | 0.062 |
CKD G2–G4 | 19 (47.5%) | 4 (17.4%) | 0.017 |
CAKUT | 24 (60%) | 12 (52.2%) | 0.546 |
Obesity | 15 (37.5%) | 3 (13%) | 0.039 |
Mineral bone disease | 2 (5%) | 1 (4.3%) | 0.907 |
Hyperlipidemia | 8 (20%) | 3 (13%) | 0.484 |
Proteinuria | 13 (32.5%) | 6 (26.1%) | 0.055 |
Hyperuricemia | 17 (42.5%) | 2 (8.7%) | 0.005 |
Abnormal ABPM | Normal ABPM | p Value | |
---|---|---|---|
n = 40 | n = 23 | ||
Body composition | |||
PBF, % | 32.4 (23.7–37.8) | 27.5 (23.7–31.7) | 0.077 |
FMI z-score | 0.45 (−0.32–1.22) | −0.41 (−0.78–−0.09) | 0.001 |
LBMI z-score | −0.3 (−1.02–0.6) | −0.59 (−1.35–−0.28) | 0.084 |
A/G ratio | 0.9 (0.81–1.04) | 0.76 (0.72–0.84) | 0.001 |
Cardiovascular assessment | |||
AASI | 0.397 (0.246–0.492) | 0.329 (0.243–0.412) | 0.084 |
LVMI, g/m2 | 32.8 (28.6–41.2) | 29.8 (26.1–38) | 0.253 |
cIMT, mm | 0.4 (0.3–0.4) | 0.3 (0.3–0.4) | 0.139 |
Factor | p Value | aOR | 95% CI | |
---|---|---|---|---|
Lower | Upper | |||
Age | 0.313 | 1.16 | 0.87 | 1.53 |
CKD stage (G2–4 vs. G1) | 0.099 | 3.69 | 0.78 | 17.39 |
Obesity | 0.523 | 0.5 | 0.06 | 4.2 |
Hyperuricemia | 0.145 | 4.24 | 0.61 | 29.49 |
FMI z-score | 0.037 | 3.0 | 1.07 | 8.46 |
A/G ratio | 0.296 | 38.8 | 0.04 | 37,000.2 |
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Hsu, C.-N.; Lu, P.-C.; Tain, Y.-L. Fat Mass Index Associated with Blood Pressure Abnormalities in Children with Chronic Kidney Disease. Children 2021, 8, 621. https://0-doi-org.brum.beds.ac.uk/10.3390/children8080621
Hsu C-N, Lu P-C, Tain Y-L. Fat Mass Index Associated with Blood Pressure Abnormalities in Children with Chronic Kidney Disease. Children. 2021; 8(8):621. https://0-doi-org.brum.beds.ac.uk/10.3390/children8080621
Chicago/Turabian StyleHsu, Chien-Ning, Pei-Chen Lu, and You-Lin Tain. 2021. "Fat Mass Index Associated with Blood Pressure Abnormalities in Children with Chronic Kidney Disease" Children 8, no. 8: 621. https://0-doi-org.brum.beds.ac.uk/10.3390/children8080621