Next Article in Journal
Characterization of Three Somatic Mutations in the 3′UTR of RRAS2 and Their Inverse Correlation with Lymphocytosis in Chronic Lymphocytic Leukemia
Previous Article in Journal
Non-Invasive Evaluation of Retinal Vascular Alterations in a Mouse Model of Optic Neuritis Using Laser Speckle Flowgraphy and Optical Coherence Tomography Angiography
Previous Article in Special Issue
A Label-Free Cell Sorting Approach to Highlight the Impact of Intratumoral Cellular Heterogeneity and Cancer Stem Cells on Response to Therapies
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cells
Volume 12
Issue 23
10.3390/cells12232686
Review Report
cells-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Review
Peer-Review Record

Metabolic Profiles of Cancer Stem Cells and Normal Stem Cells and Their Therapeutic Significance

Cells 2023, 12(23), 2686; https://0-doi-org.brum.beds.ac.uk/10.3390/cells12232686
by Ioannis Stouras 1,2,*,†, Maria Vasileiou 3,*,†, Panagiotis F. Kanatas 4, Eleni Tziona 5, Christina Tsianava 6 and Stamatis Theocharis 1
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Cells 2023, 12(23), 2686; https://0-doi-org.brum.beds.ac.uk/10.3390/cells12232686
Submission received: 16 October 2023 / Revised: 2 November 2023 / Accepted: 10 November 2023 / Published: 22 November 2023
(This article belongs to the Collection Researches on Normal and Cancer Stem Cells)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

This is an interesting and well-written review focusing on cancer stem cell (CSC) metabolism and its therapeutic implications.

The review describes the main metabolic pathways activated in both normal and tumor stem cells and presents data supporting the possible eradication of CSCs by targeting specifically activated metabolic pathways.

The authors provide a clear and comprehensive picture of CSC metabolism, I only have minor points to comment on.

·       1. In the introduction, I would recommend moving the initial part describing TME after the introduction about CSC. Furthermore, since the review is focused on the parallelism between CSCs and normal stem cells, I would emphasize and go more deeply into the commonalities and differences regarding the niche, properties and markers used for their identification.

·       2.  Chapter 2.2 is entitled Regulation, what does it mean?

·       3.  Table 1 is not of easy to understand, could you modify the graphics of the table to highlight similarities and differences between normal and CSC?

·         4.Limitations: could the authors comment on the limitation of targeting metabolic pathways with regard to normal stem cells or systemic effects?

Comments on the Quality of English Language

The English language is mostly fine

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

The manuscript by Stouras et al. compares metabolic properties of normal- and cancer stem cells (CSC) as well as summarizes therapeutic targets in regard to metabolic profile of CSC. Overall, it is an elegant summary of current knowledge about metabolic characteristics of CSC in comparison to normal stem cells. 

I find the Table 1 very confusing. The table must be properly formatted in order to make clear cut between the described metabolic pathway.

The authors aim to compare metabolism of normal stem cells and CSC. Targeting metabolic pathways in CSC seems to be very important in regard to cancer treatment. Authors should discuss whether targeting CSC can affect normal stem cells as they share some similarities.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Back to TopTop